Abstract
Scientists and healthcare providers have tried for decades to find parasite treatments that balance patient safety with efficacy in eliminating the pathogen. One approach is to target specifically the parasite’s important bodily functions while sparing the host. This brief review examines the historically significant antiparasitics - pyrethrins, picrotoxin, piperazine, and avermectins – all which specifically target parasite ion channels. We discuss the history of their discovery and use, which subsequently led to the development of new generations of parasiticides, and continues to inspire the search for safe and effective treatments.
Recommended Citation
Ricker, Josette V. and Mendenhall, Mallory
(2026)
"Ion Channels As Targets For Parasiticides: A Brief Review of Past, Present, and Future Directions,"
Georgia Journal of Science, Vol. 84, No. 2, Article 2.
Available at:
https://journal.georgiaacademyofscience.org/gjs/vol84/iss2/2